منابع مشابه
Electron tunneling in respiratory complex I.
NADH:ubiquinone oxidoreductase (complex I) plays a central role in the respiratory electron transport chain by coupling the transfer of electrons from NADH to ubiquinone to the creation of the proton gradient across the membrane necessary for ATP synthesis. Here the atomistic details of electronic wiring of all Fe/S clusters in complex I are revealed by using the tunneling current theory and co...
متن کاملTectonic evolution of the Khoy ophiolitic complex, NW Iran
The Khoy Ophiolitic Complex (KOC) as a part of Tethyan, Izmir-Ankara- Erzincan and Bitlis-Zagros sutures of South East (SE) Turkey is broadly exposed around Khoy region (NW Iran). This complex comprises dismembered fragments of mantle lithosphere, obducted oceanic lithosphere and parts of volcanic arc remnants. The Khoy Ophiolitic Complex can be structurally divided into two major eastern and w...
متن کاملStructure of the Deactive State of Mammalian Respiratory Complex I
Complex I (NADH:ubiquinone oxidoreductase) is central to energy metabolism in mammalian mitochondria. It couples NADH oxidation by ubiquinone to proton transport across the energy-conserving inner membrane, catalyzing respiration and driving ATP synthesis. In the absence of substrates, active complex I gradually enters a pronounced resting or deactive state. The active-deactive transition occur...
متن کاملThe long story of mitochondrial DNA and respiratory complex I.
This article examines the long story of the relationship between mitochondrial DNA (mtDNA) and respiratory complex I, NADH:Ubiquinone Oxidoreductase, from its beginning in the genome of the bacterial endosymbiont which then evolved into the mitochondria of our cells. The story begins with the evolution of ancient forms of bacterial complex I into the Nuo14 complex I that was present in the alp...
متن کاملThe Assembly Pathway of Mitochondrial Respiratory Chain Complex I.
Mitochondrial complex I is the largest integral membrane enzyme of the respiratory chain and consists of 44 different subunits encoded in the mitochondrial and nuclear genome. Its biosynthesis is a highly complicated and multifaceted process involving at least 14 additional assembly factors. How these subunits assemble into a functional complex I and where the assembly factors come into play is...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2011
ISSN: 0021-9258
DOI: 10.1074/jbc.m110.194993